Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.
نویسندگان
چکیده
To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.
منابع مشابه
Major histocompatibility complex controls the trajectory but not host-specific adaptation during virulence evolution of the pathogenic fungus Cryptococcus neoformans.
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عنوان ژورنال:
- Infection and immunity
دوره 71 8 شماره
صفحات -
تاریخ انتشار 2003